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Article

Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.

Human molecular genetics - 15 Jun 2017

Kharfallah Fares, Guyot Marie Claude, El Hassan Abdul Rahman, Allache Redouane, Merello Elisa, De Marco Patrizia, Di Cristo Graziella, Capra Valeria, Kibar Zoha

Abstract excerpt

Scribble1 (Scrib1) is a tumor suppressor gene that has long been established as an essential component of apicobasal polarity (ABP). In mouse models, mutations in Scrib1 cause a severe form of neural tube defects (NTDs) as a result of a defective planar cell polarity (PCP) signaling. In this study, we dissected the role of Scrib1 in the pathogenesis of NTDs in its mouse mutant Circletail (Crc), in cell lines and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28369449
DOI: 10.1093/hmg/ddx122

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