Article
CD19 expression in B cells is important for suppression of contact hypersensitivity.
The American journal of pathology - 1 Aug 2007
Watanabe Rei, Fujimoto Manabu, Ishiura Nobuko, Kuwano Yoshihiro, Nakashima Hiroko, Yazawa Norihito, Okochi Hitoshi, Sato Shinichi, Tedder Thomas F, Tamaki Kunihiko
Abstract excerpt
Contact hypersensitivity (CHS) is a cutaneous immune reaction mediated mainly by antigen-specific effector T cells and is regarded as a model for Th1/Tc1-mediated inflammation. However, recent reports have suggested pivotal roles of B cells in CHS. CD19 serves as a positive B-cell response regulator that defines signaling thresholds critical for B-cell responses. In the current study, we assessed the role of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
