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Article

Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014

Cheadle Eleanor J, Sheard Victoria, Rothwell Dominic G, Bridgeman John S, Ashton Garry, Hanson Vivien, Mansoor A Wasat, Hawkins Robert E, Gilham David E

Abstract excerpt

T cells engrafted with chimeric AgRs (CAR) are showing exciting potential for targeting B cell malignancies in early-phase clinical trials. To determine whether the second-generation CAR was essential for optimal antitumor activity, two CD28-based CAR constructs targeting CD19 were tested for their ability to redirect mouse T cell function against established B cell lymphoma in a BALB/c syngeneic model system. T...

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Share to Adoptive Transfer
Share to Antigens, CD19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Lymphoma, B-Cell

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocyte Subsets

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Source

Identifiers

PMID: 24623129
DOI: 10.4049/jimmunol.1302148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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