Article
CD19 controls Toll-like receptor 9 responses in human B cells.
The Journal of allergy and clinical immunology - 1 Mar 2016
Morbach Henner, Schickel Jean-Nicolas, Cunningham-Rundles Charlotte, Conley Mary Ellen, Reisli Ismail, Franco Jose Luis, Meffre Eric
Abstract excerpt
BACKGROUND: CD19 is a B cell-specific molecule that serves as a major costimulatory molecule for amplifying B-cell receptor (BCR) responses. Biallelic CD19 gene mutations cause common variable immunodeficiency in human subjects. BCR- and Toll-like receptor (TLR) 9-induced B-cell responses are impaired in most patients with common variable immunodeficiency. OBJECTIVE: We sought to analyze whether CD19 is required...
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