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Article

Quantitative genetic variation in CD19 expression correlates with autoimmunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2000

Sato S, Hasegawa M, Fujimoto M, Tedder T F, Takehara K

Abstract excerpt

Signaling thresholds influence the balance between humoral immunity and autoimmunity. Cell surface CD19 regulates intrinsic and Ag receptor-induced B lymphocyte signaling thresholds, and transgenic mice that overexpress CD19 by 3-fold generate spontaneous autoantibodies in a genetic background not associated with autoimmunity. To quantify the extent that genetically determined differences in expression of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11086109
DOI: 10.4049/jimmunol.165.11.6635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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