Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae.

Immunity - 1 Jul 2005

Haas Karen M, Poe Jonathan C, Steeber Douglas A, Tedder Thomas F

Abstract excerpt

B-1a and B-1b lymphocytes were found to exhibit specialized roles in providing immunity to Streptococcus pneumoniae and differ dramatically in their developmental requirements. Transgenic mice overexpressing CD19 (hCD19Tg) generated B-1a cells and natural antibodies that provided protection during infection, while CD19-deficient (CD19(-/-)) mice lacked B-1a cells, lacked natural antibodies, and were more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Bacterial
Share to Antigens, CD19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to B-Lymphocyte Subsets

Share to Immunity, Innate

Share to Immunization

Share to Pneumococcal Infections

Share to Polysaccharides, Bacterial

Share to Streptococcus pneumoniae

Source

Identifiers

PMID: 16039575
DOI: 10.1016/j.immuni.2005.04.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae.PMID 16039575Read ↗

Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression.Semantic proximity Read ↗

A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.Semantic proximity Read ↗

B1b Cells Recognize Protective Antigens after Natural Infection and VaccinationSemantic proximity Read ↗

CD1high B cells: a population of mixed origin.Semantic proximity Read ↗

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.Semantic proximity Read ↗

BAFF-driven autoimmunity requires CD19 expression.Semantic proximity Read ↗

Development, phenotype, and function of non-conventional B cells.Semantic proximity Read ↗

PI3Kδ hyper-activation promotes the development of B cells that exacerbate <i>Streptococcus pneumoniae</i> infection in an antibody-independent mannerSemantic proximity Read ↗

Regulatory roles of B cells in infectious diseases.Semantic proximity Read ↗

Human B cells promote T-cell plasticity to optimize antibody response by inducing coexpression of T(H)1/T(FH) signatures.Semantic proximity Read ↗

Role of B-1a cells in autoimmunity.Semantic proximity Read ↗

Human B-1 cells take the stage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.