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Article

Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008

Kerfoot Steven M, Szczepanik Marian, Tung James W, Askenase Philip W

Abstract excerpt

Contact sensitivity (CS) is related to delayed-type hypersensitivity and is a well-characterized prototype of T cell-mediated inflammation. However, the inflammatory response associated with CS is additionally dependent on Ag-specific IgM produced by a subpopulation of B cells in response to sensitization. Upon re-exposure to hapten, this IgM mediates rapid vascular activation and subsequent recruitment of...

Read the complete abstract on PubMed

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Dermatitis, Contact

Share to Immunoglobulin D

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Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 18641308
DOI: 10.4049/jimmunol.181.3.1717

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity.PMID 18641308Read ↗

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