Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BAFF-driven autoimmunity requires CD19 expression.

Journal of autoimmunity - 1 Aug 2015

Fairfax Kirsten A, Tsantikos Evelyn, Figgett William A, Vincent Fabien B, Quah Pin Shie, LePage Mélanie, Hibbs Margaret L, Mackay Fabienne

Abstract excerpt

B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for B cell survival and maturation. BAFF-transgenic (BAFF-Tg) mice develop autoimmunity that resembles systemic lupus erythematosus (SLE) in a T cell-independent but MyD88-dependent manner, implicating toll-like receptor (TLR) signaling. The specific B cell subtypes that make pro-inflammatory autoantibodies in BAFF-Tg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD19
Share to Autoimmunity
Share to B-Cell Activating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to B-Lymphocyte Subsets

Share to Complement C3

Share to Glomerulonephritis

Share to Immunoglobulin M

Share to Toll-Like Receptors

Source

Identifiers

PMID: 26103922
DOI: 10.1016/j.jaut.2015.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BAFF-driven autoimmunity requires CD19 expression.PMID 26103922Read ↗

B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.Semantic proximity Read ↗

An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.Semantic proximity Read ↗

Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B CellsSemantic proximity Read ↗

B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunitySemantic proximity Read ↗

B cells expressing the transcription factor T-bet drive lupus-like autoimmunitySemantic proximity Read ↗

Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression.Semantic proximity Read ↗

Enhanced Expression of Bruton's Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis.Semantic proximity Read ↗

Altered BAFF-receptor signaling and additional modifier loci contribute to systemic autoimmunity in A/WySnJ mice.Semantic proximity Read ↗

BAFF signaling in health and diseaseSemantic proximity Read ↗

Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.Semantic proximity Read ↗

TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.Semantic proximity Read ↗

Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.