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Article

The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK/STAT Pathway in a Murine Model of Allergic Conjunctivitis.

Investigative ophthalmology & visual science - 9 Mar 2020

Guo Chen, Liu Jinghua, Hao Peng, Wang Yuchuan, Sui Shuangshuang, Li Linghan, Ying Ming, Han Ruifang, Wang Liming, Li Xuan

Abstract excerpt

Purpose: Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed to examine miR-19b expression, regulation, and function in allergic conjunctivitis (AC). Methods: A murine model of experimental AC was induced in BALB/c mice by short ragweed...

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Identifiers

PMID: 32150250
DOI: 10.1167/iovs.61.3.8
PMCID: PMC7401772

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