The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis.

doi:10.1016/j.biopsych.2008.11.014

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Article

The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis.

Biological psychiatry - 1 Jun 2009

Ikram M Arfan, Liu Fan, Oostra Ben A, Hofman Albert, van Duijn Cornelia M, Breteler Monique M B

Abstract excerpt

BACKGROUND: Recently, GAB2 has been suggested to modify the risk of late-onset Alzheimer's disease (AD) among APOEepsilon4 carriers. However, replication data are inconsistent. METHODS: In a population-based cohort study (n = 5507; age > 55) with 443 incident AD cases, we investigated the association between rs4945261 and AD. Because we used high-density genotyping, we also investigated other polymorphisms within...

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Identifiers

PMID: 19118819
DOI: 10.1016/j.biopsych.2008.11.014

Genes

GAB2

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