Article
GAB2 is not associated with late-onset Alzheimer's disease in Japanese.
European journal of human genetics : EJHG - 1 May 2009
Miyashita Akinori, Arai Hiroyuki, Asada Takashi, Imagawa Masaki, Shoji Mikio, Higuchi Susumu, Urakami Katsuya, Toyabe Shinichi, Akazawa Kohei, Kanazawa Ichiro, Ihara Yasuo, Kuwano Ryozo
Abstract excerpt
The varepsilon4 allele of the apolipoprotein E gene (APOE) is unequivocally recognized as a genetic risk factor for late-onset Alzheimer's disease (LOAD). Recently, single-nucleotide polymorphisms (SNPs) of the GRB2-associated binding protein 2 gene (GAB2) were shown to be associated with LOAD in Caucasians carrying the APOE-varepsilon4 allele through a genome-wide association study. Here, we attempted to...
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