Article
Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.
Human mutation - 1 Feb 2009
Sleegers Kristel, Bettens Karolien, Brouwers Nathalie, Engelborghs Sebastiaan, van Miegroet Helen, De Deyn Peter P, Van Broeckhoven Christine
Abstract excerpt
GRB-associated binding protein 2 (GAB2) was recently reported to be a modifier of late-onset Alzheimer dementia (AD) risk in carriers of the APOE epsilon4 allele in a genome-wide association analysis. We aimed to investigate this association in a well-characterized Belgian late-onset AD patient/control group: 528 Belgian AD patients (mean onset age 79.0+/-5.2 years, 70.2% females) and 601 ethnically matched...
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