Article
Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology.
PloS one - 1 Jan 2013
Zou Fanggeng, Belbin Olivia, Carrasquillo Minerva M, Culley Oliver J, Hunter Talisha A, Ma Li, Bisceglio Gina D, Allen Mariet, Dickson Dennis W, Graff-Radford Neill R, Petersen Ronald C, Morgan Kevin, Younkin Steven G
Abstract excerpt
GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 controls) for association with LOAD. Meta-analyses revealed ORs ranging from (0.61-1.20) with no significant association...
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