Article
Casein kinase I epsilon gene transfer into the suprachiasmatic nucleus via electroporation lengthens circadian periods of tau mutant hamsters.
The European journal of neuroscience - 1 Jun 2007
Wang Haoran, Ko Caroline H, Koletar Margaret M, Ralph Martin R, Yeomans John
Abstract excerpt
Circadian activity rhythms in mammals are controlled by the expression and transcriptional regulation of clock genes in the suprachiasmatic nucleus (SCN). The circadian cycle length in hamsters is regulated in part by casein kinase I epsilon (CKIepsilon). A semidominant mutation (C-->T, R178C, CK...
Topics
- Animals
- Animals, Genetically Modified
- Casein Kinase 1 epsilon
- Circadian Rhythm
- Cricetinae
- Electroporation
- Male
- Mutation
- Suprachiasmatic Nucleus
- Time Factors
- Transcription, Genetic
- tau Proteins