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Article

Constitutive expression of the <i>Period1</i> gene impairs behavioral and molecular circadian rhythms

28 Feb 2006

Abstract excerpt

Three mammalian Period (Per) genes, termed Per1, Per2, and Per3, have been identified as structural homologues of the Drosophila circadian clock gene, period (per). The three Per genes are rhythmically expressed in the suprachiasmatic nucleus (SCN), the central circadian pacemaker in mammals. The phases of peak mRNA levels for the three Per genes in the SCN are slightly different. Light sequentially induces the...

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Identifiers

PMID: 16537451
DOI: 10.1073/pnas.0600060103

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