Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.

Nature immunology - 1 Jul 2007

Fraenkel Shira, Mostoslavsky Raul, Novobrantseva Tatiana I, Pelanda Roberta, Chaudhuri Jayanta, Esposito Gloria, Jung Steffen, Alt Frederick W, Rajewsky Klaus, Cedar Howard, Bergman Yehudit

Abstract excerpt

Monoallelic demethylation and rearrangement control allelic exclusion of the immunoglobulin kappa-chain locus (Igk locus) in B cells. Here, through the introduction of pre-rearranged Igk genes into their physiological position, the critical rearrangement step was bypassed, thereby generating mice producing B cells simultaneously expressing two different immunoglobulin-kappa light chains. Such 'double-expressing'...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Diversity
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Rearrangement, B-Lymphocyte

Share to Immunoglobulin kappa-Chains

Share to Immunoglobulin Variable Region

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 17546032
DOI: 10.1038/ni1476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.PMID 17546032Read ↗

Rearrangement/hypermutation/gene conversion: when, where and why?Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation.Semantic proximity Read ↗

Kappa chain monoallelic demethylation and the establishment of allelic exclusion.Semantic proximity Read ↗

Epigenetic ontogeny of the Igk locus during B cell development.Semantic proximity Read ↗

Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.Semantic proximity Read ↗

Clonally stable Vκ allelic choice instructs Igκ repertoire.Semantic proximity Read ↗

A Multifunctional Element in the Mouse Igκ Locus That Specifies Repertoire and Ig Loci Subnuclear LocationSemantic proximity Read ↗

Antibody diversity: a link between switching and hypermutation.Semantic proximity Read ↗

Allelic exclusion of immunoglobulin genes: models and mechanisms.Semantic proximity Read ↗

Differential accessibility at the kappa chain locus plays a role in allelic exclusion.Semantic proximity Read ↗

Clonal allelic predetermination of immunoglobulin-κ rearrangement.Semantic proximity Read ↗

Re-organization of the immunoglobulin kappa gene on both alleles is not an obligatory prerequisite for Ig lambda gene expression in human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.