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Article

Allelic exclusion of immunoglobulin genes: models and mechanisms.

Immunological reviews - 1 Sept 2010

Vettermann Christian, Schlissel Mark S

Abstract excerpt

The allelic exclusion of immunoglobulin (Ig) genes is one of the most evolutionarily conserved features of the adaptive immune system and underlies the monospecificity of B cells. While much has been learned about how Ig allelic exclusion is established during B-cell development, the relevance of monospecificity to B-cell function remains enigmatic. Here, we review the theoretical models that have been proposed...

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Identifiers

PMID: 20727027
DOI: 10.1111/j.1600-065X.2010.00935.x
PMCID: PMC2928156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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