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Article

Kappa chain monoallelic demethylation and the establishment of allelic exclusion.

Genes & development - 15 Jun 1998

Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y

Abstract excerpt

Allelic exclusion in kappa light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional kappa light chain on the surface of the B cell leads to an intracellular signal that down-regulates the V(D)J recombinase, thus precluding rearrangement of the o...

Topics

Alleles
Animals
B-Lymphocytes
DNA Methylation
Enhancer Elements, Genetic
Gene Expression Regulation, Developmental
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Knockout

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 9637682
DOI: 10.1101/gad.12.12.1801
PMCID: PMC316908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9637682-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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