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Article

Kappa chain monoallelic demethylation and the establishment of allelic exclusion.

Genes & development - 15 Jun 1998

Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y

Abstract excerpt

Allelic exclusion in kappa light-chain synthesis is thought to result from a feedback mechanism by which the expression of a functional kappa light chain on the surface of the B cell leads to an intracellular signal that down-regulates the V(D)J recombinase, thus precluding rearrangement of the other allele. Whereas such a feedback mechanism clearly plays a role in the maintenance of allelic exclusion, here we...

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Identifiers

PMID: 9637682
DOI: 10.1101/gad.12.12.1801
PMCID: PMC316908

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