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Article

Re-organization of the immunoglobulin kappa gene on both alleles is not an obligatory prerequisite for Ig lambda gene expression in human cells.

Immunology - 1 Dec 1991

Abken H, Bützler C

Abstract excerpt

Re-arrangement and expression of the immunoglobulin (Ig) genes in B cells occurs under an ordered developmental control. The sequential model of Ig light chain exclusion predicts that only after non-productive re-organization or deletion of both Ig kappa alleles would re-arrangement of Ig lambda gene segments occur. To prove this model, we asked whether expression of Ig lambda light chains is always associated...

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Identifiers

PMID: 1783429
PMCID: PMC1384784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Re-organization of the immunoglobulin kappa gene on both alleles is not an obligatory prerequisite for Ig lambda gene expression in human cells.PMID 1783429Read ↗

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Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the humanSemantic proximity Read ↗

Allelic exclusion of immunoglobulin gene rearrangement and expression: why and how?Semantic proximity Read ↗

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