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Article

Antibody diversity: a link between switching and hypermutation.

Current biology : CB - 2 Nov 2000

Lieber M

Abstract excerpt

Recent work indicates that mutations in a cytidine deaminase homologue ablate both immunoglobulin class switch recombination and somatic hypermutation. These findings now explain cases of autosomal hyper-IgM syndrome and reveal that critical components for key functions of B cells require RNA editing.

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Antibody Diversity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunoglobulin Class Switching

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Source

Identifiers

PMID: 11084354
DOI: 10.1016/s0960-9822(00)00766-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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