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Article

Differential accessibility at the kappa chain locus plays a role in allelic exclusion.

The EMBO journal - 1 Oct 2002

Goldmit Maya, Schlissel Mark, Cedar Howard, Bergman Yehudit

Abstract excerpt

Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin kappa locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one allele with a higher probability than the other. It may be this process that, together with feedback inhibition,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12356741
DOI: 10.1093/emboj/cdf518
PMCID: PMC129040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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