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Article

Clonally stable Vκ allelic choice instructs Igκ repertoire.

Nature communications - 30 May 2017

Levin-Klein Rena, Fraenkel Shira, Lichtenstein Michal, Matheson Louise S, Bartok Osnat, Nevo Yuval, Kadener Sebastian, Corcoran Anne E, Cedar Howard, Bergman Yehudit

Abstract excerpt

Although much has been done to understand how rearrangement of the Igκ locus is regulated during B-cell development, little is known about the way the variable (V) segments themselves are selected. Here we show, using B6/Cast hybrid pre-B-cell clones, that a limited number of V segments on each allele is stochastically activated as characterized by the appearance of non-coding RNA and histone modifications. The...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28555639
DOI: 10.1038/ncomms15575
PMCID: PMC5459994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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