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Article

Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs

15 May 2007

Abstract excerpt

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and hepatocellular carcinoma, yet fully efficacious treatments are missing. In this study, we investigated RNA interference (RNAi), a specific gene silencing process mediated by small interfering RNA (siRNA) duplexes, as an antiviral strategy against HCV. Synthetic siRNAs were designed to target conserved sequences of the HCV 5'...

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PMID: 17505476
DOI: 10.1038/sj.mt.6300186

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