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Article

Interference of hepatitis C virus RNA replication by short interfering RNAs

3 Feb 2003

Abstract excerpt

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, which can lead to the development of liver cirrhosis and hepatocellular carcinoma. Current therapy of patients with chronic HCV infection includes treatment with IFNalpha in combination with ribavirin. Because most treated patients do not resolve the infection, alternative treatment is essential. RNA interference (RNAi) is a recently...

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PMID: 12566571
DOI: 10.1073/pnas.252783999

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