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Article

Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot.

PloS one - 1 Jan 2016

Moon Jae-Su, Lee Seung-Hoon, Kim Eun-Jung, Cho Hee, Lee Wooseong, Kim Geon-Woo, Park Hyun-Ji, Cho Seung-Woo, Lee Choongho, Oh Jong-Won

Abstract excerpt

The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent viral translation is a primary target for small interfering RNA (siRNA)-based HCV antiviral therapy. However, identification of potent siRNAs against HCV IRES by bioinformatics-based siRNA design is a challenging task given the complexity of HCV IRES secondary and tertiary structures and association with multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26751678
DOI: 10.1371/journal.pone.0146710
PMCID: PMC4713436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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