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Article

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003

Wilson Joyce A, Jayasena Sumedha, Khvorova Anastasia, Sabatinos Sarah, Rodrigue-Gervais Ian Gaël, Arya Sudha, Sarangi Farida, Harris-Brandts Marees, Beaulieu Sylvie, Richardson Christopher D

Abstract excerpt

RNA interference represents an exciting new technology that could have therapeutic applications for the treatment of viral infections. Hepatitis C virus (HCV) is a major cause of chronic liver disease and affects >270 million individuals worldwide. The HCV genome is a single-stranded RNA that functions as both a messenger RNA and replication template, making it an attractive target for the study of RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12594341
DOI: 10.1073/pnas.252758799
PMCID: PMC151418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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