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Therapeutic application of RNA interference for hepatitis C virus.

Advanced drug delivery reviews - 10 Oct 2007

Watanabe Tsunamasa, Umehara Takuya, Kohara Michinori

Abstract excerpt

RNA interference (RNAi) is a sequence-specific post-transcriptional gene silencing by double-stranded RNA. Because the phenomenon is conserved and ubiquitous in mammalian cells, RNAi has considerable therapeutic potential for human pathogenic gene products. Recent studies have demonstrated the clinical potential of logically designed small interfering RNA (siRNA). However, there are still obstacles in using RNAi...

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Genetic Vectors
Hepacivirus
Hepatitis C
Models, Biological
Mutation
RNA Interference

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Small Interfering

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PMID: 17822803
DOI: 10.1016/j.addr.2007.03.022

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