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Article

Small Interfering RNA-Mediated Inhibition of Hepatitis C Virus Replication in the Human Hepatoma Cell Line Huh-7

11 Dec 2002

Abstract excerpt

RNA interference (RNAi) is a process of posttranscriptional gene silencing in plants, insects, and animals (4, 7, 13, 14). In vivo, RNAi is initiated by an endonuclease, DICER, that cleaves long, double-stranded RNA into 21- to 25-bp small interfering RNAs (siRNAs) (2, 3, 6, 15). siRNAs are incorporated into a protein complex, the RNAi silencing complex, that recognizes and cleaves target mRNAs (12). Inhibition...

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PMID: 12477890
DOI: 10.1128/jvi.77.1.810-812.2003

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