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Article

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2003

Randall Glenn, Grakoui Arash, Rice Charles M

Abstract excerpt

RNA interference is a cellular process of gene silencing in which small duplexes of RNA specifically target a homologous sequence for cleavage by cellular ribonucleases. The introduction of approximately 22-nt small interfering RNAs (siRNAs) into mammalian cells can specifically silence cellular mRNAs without induction of the nonspecific IFN responses that are activated by longer RNA duplexes. We investigate in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12518066
DOI: 10.1073/pnas.0235524100
PMCID: PMC140937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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