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Article

In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes.

PloS one - 1 Jan 2016

ElHefnawi Mahmoud, Kim TaeKyu, Kamar Mona A, Min Saehong, Hassan Nafisa M, El-Ahwany Eman, Kim Heeyoung, Zada Suher, Amer Marwa, Windisch Marc P

Abstract excerpt

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs (siRNAs) targeting highly conserved regions of the hepatitis C virus (HCV) genome. To aim for therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27441640
DOI: 10.1371/journal.pone.0159211
PMCID: PMC4956106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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