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Article

Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs.

Journal of virology - 1 Apr 2004

Krönke Jan, Kittler Ralf, Buchholz Frank, Windisch Marc P, Pietschmann Thomas, Bartenschlager Ralf, Frese Michael

Abstract excerpt

Persistent infection with hepatitis C virus (HCV) is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. It has recently been shown that HCV RNA replication is susceptible to small interfering RNAs (siRNAs), but the antiviral activity of siRNAs depends very much on their complementarity to the target sequence. Thus, the high degree of sequence diversity between different HCV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15016866
DOI: 10.1128/jvi.78.7.3436-3446.2004
PMCID: PMC371081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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