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Article

FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest.

The Journal of cell biology - 19 Aug 2002

Laplantine Emmanuel, Rossi Ferdinand, Sahni Malika, Basilico Claudio, Cobrinik David

Abstract excerpt

Unregulated FGF signaling affects endochondral ossification and long bone growth, causing several genetic forms of human dwarfism. One major mechanism by which FGFs regulate endochondral bone growth is through their inhibitory effect on chondrocyte proliferation. Because mice with targeted mutations of the retinoblastoma (Rb)-related proteins p107 and p130 present severe endochondral bone defects with excessive...

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Identifiers

PMID: 12177046
DOI: 10.1083/jcb.200205025
PMCID: PMC2174007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest.PMID 12177046Read ↗

A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiationSemantic proximity Read ↗

Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.Semantic proximity Read ↗

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2.Semantic proximity Read ↗

Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and DifferentiationSemantic proximity Read ↗

Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.Semantic proximity Read ↗

Chondrogenesis and osteogenesis are one continuous developmental and lineage defined biological processSemantic proximity Read ↗

FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells.Semantic proximity Read ↗

Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.Semantic proximity Read ↗

G1 arrest and differentiation can occur independently of Rb family functionSemantic proximity Read ↗

Cell cycle regulators control mesoderm specification in human pluripotent stem cellsSemantic proximity Read ↗

Negative Regulation of DNA Replication by the Retinoblastoma Protein Is Mediated by Its Association with MCM7Semantic proximity Read ↗

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.Semantic proximity Read ↗

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