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Article

p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.

The Journal of clinical investigation - 1 Mar 2012

Serres Murielle P, Kossatz Uta, Chi Yong, Roberts James M, Malek Nisar P, Besson Arnaud

Abstract excerpt

p27(Kip1) (p27) acts as a tumor suppressor by inhibiting cyclin-cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27(CK-)) have increased incidence of tumor development as compared with wild-type and p27(-/-) mice, revealing an oncogenic role for p27. Here, we identified a phenotype of multinucleation and polyploidy in...

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Identifiers

PMID: 22293177
DOI: 10.1172/JCI60376
PMCID: PMC3287231

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