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Article

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 1999

Park M S, Rosai J, Nguyen H T, Capodieci P, Cordon-Cardo C, Koff A

Abstract excerpt

The commitment of cells to replicate and divide correlates with the activation of cyclin-dependent kinases and the inactivation of Rb, the product of the retinoblastoma tumor suppressor gene. Rb is a target of the cyclin-dependent kinases and, when phosphorylated, is inactivated. Biochemical studies exploring the nature of the relationship between cyclin-dependent kinase inhibitors and Rb have supported the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10339596
DOI: 10.1073/pnas.96.11.6382
PMCID: PMC26890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.PMID 10339596Read ↗

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