Article
Generation of mice deficient for Lbx2, a gene expressed in the urogenital system, nervous system, and Pax3 dependent tissues.
Genesis (New York, N.Y. : 2000) - 1 Jun 2007
Wei Ke, Chen Jiyuan, Akrami Kevan, Sekhon Rashmi, Chen Fabian
Abstract excerpt
Lbx2 is a member of the ladybird family of homeobox genes. The first murine ortholog identified, Lbx1, is required for hypaxial musculature and dorsal spinal cord neuron development. The second murine ortholog, Lbx2, is expressed in the developing urogenital and nervous systems. To elucidate the function of Lbx2, we generated a gene-targeted allele of Lbx2 in mice. Lbx2 deficiency did not impair mouse...
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