Article
Generation of mice with conditional null allele for GdX/Ubl4A.
Genesis (New York, N.Y. : 2000) - 1 Jul 2012
Wang Yangmeng, Wang Dianjun, Ren Fangli, Zhang Yuanjiang, Lin Fuyu, Hou Ning, Cheng Xuan, Zhang Peng, Wang Yinyin, Jia Baoqing, Yang Xiao, Chang Zhijie
Abstract excerpt
GdX (also named Ubl4A) is a house-keeping gene located on the X chromosome and encodes a protein harboring an ubiquitin-like domain in human and mouse. Although identified in 1988, the function of GdX remains unknown. To elucidate the role of GdX in vivo, we generated a conditional GdX knockout mouse in which Exon 2 was flanked by two loxP sites. We obtained viable and fertile mice with homozygous GdX(flox/flox)...
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