Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.

doi:10.1101/gad.9.20.2523

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Article

Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.

Genes & development - 15 Oct 1995

Qiu M, Bulfone A, Martinez S, Meneses J J, Shimamura K, Pedersen R A, Rubenstein J L

Abstract excerpt

Genetic analysis of the development and evolution of the vertebrate head is at a primitive stage. Many homeo box genes, including the Distal-less family, are potential regulators of head development. To determine the function of Dlx-2, we generated a null mutation in mice using gene targeting. In...

Topics

Animals
Base Sequence
Branchial Region
Cell Differentiation
Cytoskeletal Proteins
DNA Primers
DNA-Binding Proteins
Face
Gene Targeting
Homeodomain Proteins
Homozygote
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Morphogenesis

Mutation

Olfactory Bulb

Prosencephalon

RNA-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 7590232
DOI: 10.1101/gad.9.20.2523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7590232-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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