Article
The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
Neuron - 16 May 2002
Müller Thomas, Brohmann Henning, Pierani Alessandra, Heppenstall Paul A, Lewin Gary R, Jessell Thomas M, Birchmeier Carmen
Abstract excerpt
Dorsal horn neurons in the spinal cord integrate and relay sensory information. Here, we show that the expression of the homeobox gene Lbx1 distinguishes two major neuronal classes generated in the dorsal spinal cord. The Lbx1(-) (class A) and Lbx1(+) (class B) neurons differ in their dependence on roof plate BMP signals for specification and settle in the deep and superficial dorsal horn, respectively. Lbx1...
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