Article
The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts.
The EMBO journal - 15 Feb 2001
Wang W, Czaplinski K, Rao Y, Peltz S W
Abstract excerpt
The yeast UPF1, UPF2 and UPF3 genes encode trans-acting factors of the nonsense-mediated mRNA decay pathway. In addition, the upf1Delta strain demonstrates a nonsense suppression phenotype and Upf1p has been shown to interact with the release factors eRF1 and eRF3. In this report, we show that both upf2Delta and upf3Delta strains demonstrate a nonsense suppression phenotype independent of their effect on mRNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.