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Article

Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p.

Molecular and cellular biology - 1 Jul 2000

Maderazo A B, He F, Mangus D A, Jacobson A

Abstract excerpt

Upf1p, Nmd2p, and Upf3p regulate the degradation of yeast mRNAs that contain premature translation termination codons. These proteins also appear to regulate the fidelity of termination, allowing translational suppression in their absence. Here, we have devised a novel quantitative assay for translational suppression, based on a nonsense allele of the CAN1 gene (can1-100), and used it to determine the regulatory...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10848586
DOI: 10.1128/MCB.20.13.4591-4603.2000
PMCID: PMC85857

Genes

UPF1
XRN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p.PMID 10848586Read ↗

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A highly conserved region essential for NMD in the Upf2 N-terminal domain.Semantic proximity Read ↗

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.Semantic proximity Read ↗

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.Semantic proximity Read ↗

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