Functional mapping of the translation-dependent instability element of yeast MATalpha1 mRNA.

doi:10.1128/MCB.16.7.3833

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Article

Functional mapping of the translation-dependent instability element of yeast MATalpha1 mRNA.

Molecular and cellular biology - 1 Jul 1996

Hennigan A N, Jacobson A

Abstract excerpt

The determinants of mRNA stability include specific cis-acting destabilizing sequences located within mRNA coding and noncoding regions. We have developed an approach for mapping coding-region instability sequences in unstable yeast mRNAs that exploits the link between mRNA translation and turnover and the dependence of nonsense-mediated mRNA decay on the activity of the UPF1 gene product. This approach, which...

Topics

Alleles
Base Sequence
Codon
Fungal Proteins
Genes, Fungal
Mating Factor
Molecular Sequence Data
Mutagenesis, Site-Directed
Oligodeoxyribonucleotides
Peptide Biosynthesis
Peptide Chain Termination, Translational
Peptides
Pheromones
Plasmids
Protein Biosynthesis
RNA Helicases
RNA, Messenger
Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8668201
DOI: 10.1128/MCB.16.7.3833
PMCID: PMC231380

Genes

UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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