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Article

Functional mapping of the translation-dependent instability element of yeast MATalpha1 mRNA.

Molecular and cellular biology - 1 Jul 1996

Hennigan A N, Jacobson A

Abstract excerpt

The determinants of mRNA stability include specific cis-acting destabilizing sequences located within mRNA coding and noncoding regions. We have developed an approach for mapping coding-region instability sequences in unstable yeast mRNAs that exploits the link between mRNA translation and turnover and the dependence of nonsense-mediated mRNA decay on the activity of the UPF1 gene product. This approach, which...

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Identifiers

PMID: 8668201
DOI: 10.1128/MCB.16.7.3833
PMCID: PMC231380

Genes

UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional mapping of the translation-dependent instability element of yeast MATalpha1 mRNA.PMID 8668201Read ↗

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.Semantic proximity Read ↗

An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.Semantic proximity Read ↗

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.Semantic proximity Read ↗

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.Semantic proximity Read ↗

Upf1 and Upf2 proteins mediate normal yeast mRNA degradation when translation initiation is limited.Semantic proximity Read ↗

Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay.Semantic proximity Read ↗

Messenger RNA stability in yeast.Semantic proximity Read ↗

ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities.Semantic proximity Read ↗

Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p.Semantic proximity Read ↗

A single amino acid substitution in yeast eIF-5A results in mRNA stabilization.Semantic proximity Read ↗

A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability.Semantic proximity Read ↗

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