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Article

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

Genes & development - 1 Sept 1993

Peltz S W, Brown A H, Jacobson A

Abstract excerpt

Nonsense mutations in a gene can accelerate the decay rate of the mRNA transcribed from that gene, a phenomenon we describe as nonsense-mediated mRNA decay. Using amber (UAG) mutants of the yeast PGK1 gene as a model system, we find that nonsense-mediated mRNA decay is position dependent, that is, nonsense mutations within the initial two-thirds of the PGK1-coding region accelerate the decay rate of the PGK1...

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Source

Identifiers

PMID: 8370523
DOI: 10.1101/gad.7.9.1737

Genes

PGK1
UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.PMID 8370523Read ↗

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