Article
Overexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance.
Molecular microbiology - 1 Feb 2004
de Pinto B, Lippolis R, Castaldo R, Altamura N
Abstract excerpt
In yeast the UPF1, UPF2 and UPF3 genes encode three interacting factors involved in translation termination and nonsense-mediated mRNA decay (NMD). UPF1 plays a central role in both processes. In addition, UPF1 was originally isolated as a multicopy suppressor of mitochondrial splicing deficiency, and its deletion leads to an impairment in respiratory growth. Here, we provide evidence that inactivation of UPF2 or...
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