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Article

Immunochemical localization and functional characterization of cytochrome P450IIE1 in rat hepatocyte foci and nodules.

Carcinogenesis - 1 Dec 1991

Kobusch A B, Schrenk D, Gans G, Münzel P, Werringloer J, Ingelman-Sundberg M, Bock K W

Abstract excerpt

P450IIE1 was studied in rat hepatocyte foci and nodules from male Wistar rats, treated for 7 weeks with N-nitroso-morpholine (20, 40 and 80 mg/ml of drinking water). Livers were examined after 15, 23 and 31 weeks. Using specific anti-P450IIE1 IgG, different phenotypes of P450IIE1-altered foci were observed: (i) positive foci, predominant at early times and at the two lower dosages, (ii) negative foci and (iii)...

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PMID: 1747939
DOI: 10.1093/carcin/12.12.2353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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