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Article

Immunochemical localization and functional characterization of cytochrome P450IIE1 in rat hepatocyte foci and nodules.

Carcinogenesis - 1 Dec 1991

Kobusch A B, Schrenk D, Gans G, Münzel P, Werringloer J, Ingelman-Sundberg M, Bock K W

Abstract excerpt

P450IIE1 was studied in rat hepatocyte foci and nodules from male Wistar rats, treated for 7 weeks with N-nitroso-morpholine (20, 40 and 80 mg/ml of drinking water). Livers were examined after 15, 23 and 31 weeks. Using specific anti-P450IIE1 IgG, different phenotypes of P450IIE1-altered foci wer...

Topics

Animals
Blotting, Western
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Hyperplasia
Immunochemistry
Liver
Liver Neoplasms, Experimental
Male
Microsomes, Liver
Morpholines
Oxidoreductases, N-Demethylating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Rats

Rats, Inbred Strains

Source

Identifiers

PMID: 1747939
DOI: 10.1093/carcin/12.12.2353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1747939-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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