Enhancement and phenotypic modulation of N-nitrosomorpholine-induced hepatocarcinogenesis by dehydroepiandrosterone.

doi:10.1016/s0304-3835(97)00341-8

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Article

Enhancement and phenotypic modulation of N-nitrosomorpholine-induced hepatocarcinogenesis by dehydroepiandrosterone.

Cancer letters - 23 Dec 1997

Metzger C, Bannasch P, Mayer D

Abstract excerpt

Hepatocarcinogenesis was induced in male and female rats by continuous administration of the adrenal steroid dehydroepiandrosterone (DHEA; 0.6% in the diet) with and without previous treatment with N-nitrosomorpholine (NNM; 120 mg/l drinking water for 7 weeks). DHEA treatment alone resulted in he...

Topics

Adenoma, Liver Cell
Animals
Carcinogens
Carcinoma, Hepatocellular
Dehydroepiandrosterone
Drug Synergism
Female
Incidence
Liver Neoplasms, Experimental
Male
Nitrosamines
Phenotype
Rats
Rats, Sprague-Dawley
Statistics as Topic

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