Article
Rapid induction of preneoplastic liver foci in embryonal turkey liver by diethylnitrosamine.
Toxicologic pathology - 1 Jan 2000
Enzmann H, Kühlem C, Kaliner G, Löser E, Bannasch P
Abstract excerpt
Diethylnitrosamine (DEN) was injected into fertilized turkey eggs. After incubation for 24 days, the livers of the embryos were removed and investigated by means of histological and enzyme-histochemical methods. Doses of 2 and 5 mg DEN per egg had no effect on mortality and embryo weight but induced various types of foci of altered hepatocytes. In addition, a replacement of the trabecular structure of the liver...
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