Article
Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver.
Carcinogenesis - 1 Nov 1996
Tsuda H, Asamoto M, Iwahori Y, Hori T, Ota T, Baba-Toriyama H, Uehara N, Kim D J, Krutovskikh V A, Takasuka N, Tsuchiya T, Mutai M, Tatematsu M, Yamasaki H
Abstract excerpt
Two different types of focal preneoplastic lesions, tentatively named Type I and II lesions, were recognized in the liver of rats chronically treated with clofibrate for 104 weeks. Type I lesions were characterized by mostly negative glucose-6-phosphate dehydrogenase (G6PD) activity (6 out of 10,...
Topics
- Animals
- Carcinogens
- Clofibrate
- Connexins
- Diethylnitrosamine
- Glutathione Transferase
- Liver Neoplasms, Experimental
- Male
- Microbodies
- Phenotype
- Precancerous Conditions
- Rats
- Rats, Wistar
- gamma-Glutamyltransferase