Article
Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver.
Carcinogenesis - 1 Nov 1996
Tsuda H, Asamoto M, Iwahori Y, Hori T, Ota T, Baba-Toriyama H, Uehara N, Kim D J, Krutovskikh V A, Takasuka N, Tsuchiya T, Mutai M, Tatematsu M, Yamasaki H
Abstract excerpt
Two different types of focal preneoplastic lesions, tentatively named Type I and II lesions, were recognized in the liver of rats chronically treated with clofibrate for 104 weeks. Type I lesions were characterized by mostly negative glucose-6-phosphate dehydrogenase (G6PD) activity (6 out of 10, 60%) and positive expression of succinate dehydrogenase (10 out of 10, 100%), in addition to the previously documented...
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