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Article

DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.

Cancer research - 15 Aug 1990

Schulte-Hermann R, Timmermann-Trosiener I, Barthel G, Bursch W

Abstract excerpt

Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine; subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg body weight for up to 49 weeks. Subgroups of rats were left untreated after 10 or 28 weeks on PB. PB produced the following changes: (a) accelerated appearance of neoplastic nodules and hepatocellular carcinoma (from 28 weeks onwards);...

Topics

Animals
Body Weight
Carcinogens
Cell Division
DNA Replication
Female
Liver
Liver Neoplasms
Nitrosamines
Organ Size
Phenobarbital
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precancerous Conditions

Rats

Rats, Inbred Strains

Thymidine

Source

Identifiers

PMID: 2379175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2379175-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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