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Article

Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma.

International journal of cancer - 15 Aug 2007

Ollikainen Miina, Gylling Annette, Puputti Marjut, Nupponen Nina N, Abdel-Rahman Wael M, Butzow Ralf, Peltomäki Päivi

Abstract excerpt

While the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is known to be activated in multiple sporadic cancers, the role of this pathway in familial tumors is mostly unknown. We searched for alterations in the catalytic domain of PI3K (PIK3CA), PTEN and KRAS, all of which may contribute to PI3K/AKT pathway activation, in a total of 160-familial colorectal (CRC) and endometrial carcinomas (EC),...

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Share to Class I Phosphatidylinositol 3-Kinases
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Phosphatidylinositol 3-Kinases

Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Proteins p21(ras)

Share to PTEN Phosphohydrolase

Share to ras Proteins

Source

Identifiers

PMID: 17471559
DOI: 10.1002/ijc.22768

Genes

KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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