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Article

Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.

Journal of cancer research and clinical oncology - 1 Mar 2012

Wang Li-E, Ma Hongxia, Hale Katherine S, Yin Ming, Meyer Larissa A, Liu Hongliang, Li Jie, Lu Karen H, Hennessy Bryan T, Li Xuesong, Spitz Margaret R, Wei Qingyi, Mills Gordon B

Abstract excerpt

PURPOSE: The phosphatidylinositol 3-kinase (PI3K)/PTEN/AKT/mTOR and Ras/Raf/MEK/ERK pathways have been implicated in endometrial tumorigenesis. In this candidate pathway analysis, we investigated associations between genetic variations in these two pathways and both risk and clinical outcomes of endometrial cancer. METHODS: We genotyped a total of 48 potentially functional SNPs in 11 key genes (AKT1, AKT2, AKT3,...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proportional Hazards Models

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Source

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Identifiers

PMID: 22146979
DOI: 10.1007/s00432-011-1103-0
PMCID: PMC3526101

Genes

PIK3CA
AKT1
AKT2
KRAS
PTEN
AKT3
BRAF
PDPK1
PIK3CB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.PMID 22146979Read ↗

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